Oral immunization with a model protein entrapped in microspheres prepared from derivatized alpha-amino acids.

A model antigen, ovalbumin (OVA), was encapsulated in microspheres prepared from derivatized alpha-amino acids and administered orally to mice. These microspheres are quickly and easily prepared, without the use of organic solvents, high temperatures, or complex purification techniques. Immunological responses included induction of OVA-specific antibodies… (More)