Oral hydrocortisone pharmacokinetics: a comparison of fluorescence and ultraviolet high-pressure liquid chromatographic assays for hydrocortisone in plasma.

@article{Toothaker1982OralHP,
  title={Oral hydrocortisone pharmacokinetics: a comparison of fluorescence and ultraviolet high-pressure liquid chromatographic assays for hydrocortisone in plasma.},
  author={Roger D. Toothaker and G M Sundaresan and John Patrick Hunt and Thomas J. Goehl and K. S. Rotenberg and Vadlamani K. Prasad and William A P Craig and Peter G. Welling},
  journal={Journal of pharmaceutical sciences},
  year={1982},
  volume={71 5},
  pages={
          573-6
        }
}
Three fasted, male subjects received single 10-, 30-, and 50-mg oral doses of hydrocortisone tablets on separate occasions. Endogenous hydrocortisone was suppressed by giving 2 mg of dexamethasone 9 hr prior to dosing. Plasma samples obtained serially for 8 hr after hydrocortisone dosing were assayed by reversed-phase high-pressure liquid chromatography (HPLC) with UV detection and by normal-phase HPLC with fluorescence detection of the dansylhydrazine derivative of hydrocortisone. The two… CONTINUE READING

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