Oral heparin delivery: design and in vivo evaluation of a stomach-targeted mucoadhesive delivery system.

@article{Schmitz2005OralHD,
  title={Oral heparin delivery: design and in vivo evaluation of a stomach-targeted mucoadhesive delivery system.},
  author={Thierry Schmitz and Verena Leitner and Andreas Bernkop-Schn{\"u}rch},
  journal={Journal of pharmaceutical sciences},
  year={2005},
  volume={94 5},
  pages={966-73}
}
Low molecular weight heparin (LMWH) is an agent of choice in the anti-coagulant therapy and prophylaxis of thrombosis and coronary syndromes. However, the therapeutic use is partially limited due to a poor oral bioavailability. It was therefore the aim of this study to design and evaluate a highly efficient stomach-targeted oral delivery system for LMWH. In order to appraise the influence of the molecular weight on the oral bioavailability, mini-tablets comprising 3 kDa (279 IU) and 6 kDa (300… CONTINUE READING