Haloperidol ( but not risperidone ) was associated with impairments in water maze hidden platform trial performance at each of the time periods evaluated up to 45 days , but not when tested during days 83 - 90 .
Oral haloperidol or risperidone treatment in rats : temporal effects on nerve growth factor receptors , cholinergic neurons , and memory performance .
Further , haloperidol was associated with decrements in short delay performance in the spontaneous novel object recognition task during both the 8 - 14 and 31 - 38 day periods of treatment , while risperidone was associated with short delay impairment during the 31 - 38 day time period .
These data from rats support the notion that while risperidone may hold some advantages over haloperidol , both antipsychotics can produce time - dependent alterations in neurotrophin receptors and cholinergic proteins as well as impairments in the performance of tasks designed to assess spatial learning and episodic memory .
In this rodent study the effects of different time periods ( ranging from 2 weeks to 6 months ) of oral treatment with the FGA , haloperidol ( 2.0 mg / kg / day ) , or the SGA , risperidone ( 2.5 mg / kg / day ) on a water maze repeated acquisition procedure , the levels of nerve growth factor receptors , and two important cholinergic proteins , the vesicular acetylcholine transporter and the high affinity choline transporter were evaluated .