Oral haloperidol or risperidone treatment in rats: temporal effects on nerve growth factor receptors, cholinergic neurons, and memory performance.

@article{Terry2007OralHO,
  title={Oral haloperidol or risperidone treatment in rats: temporal effects on nerve growth factor receptors, cholinergic neurons, and memory performance.},
  author={Alvin V. Terry and Debra A. Gearhart and Samantha E. Warner and G Y Zhang and Michael G Bartlett and M-L Middlemore and Wayne D. Beck and Sahebarao Prabhu Mahadik and Jennifer L Waller},
  journal={Neuroscience},
  year={2007},
  volume={146 3},
  pages={1316-32}
}
First and second generation antipsychotics (FGAs and SGAs) ameliorate psychotic symptoms of schizophrenia, however, their chronic effects on information processing and memory function (i.e. key determinants of long term functional outcome) are largely unknown. In this rodent study the effects of different time periods (ranging from 2 weeks to 6 months) of oral treatment with the FGA, haloperidol (2.0 mg/kg/day), or the SGA, risperidone (2.5 mg/kg/day) on a water maze repeated acquisition… CONTINUE READING

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These data from rats support the notion that while risperidone may hold some advantages over haloperidol , both antipsychotics can produce time - dependent alterations in neurotrophin receptors and cholinergic proteins as well as impairments in the performance of tasks designed to assess spatial learning and episodic memory .
Haloperidol ( but not risperidone ) was associated with impairments in water maze hidden platform trial performance at each of the time periods evaluated up to 45 days , but not when tested during days 83 - 90 .
Oral haloperidol or risperidone treatment in rats : temporal effects on nerve growth factor receptors , cholinergic neurons , and memory performance .
Further , haloperidol was associated with decrements in short delay performance in the spontaneous novel object recognition task during both the 8 - 14 and 31 - 38 day periods of treatment , while risperidone was associated with short delay impairment during the 31 - 38 day time period .
These data from rats support the notion that while risperidone may hold some advantages over haloperidol , both antipsychotics can produce time - dependent alterations in neurotrophin receptors and cholinergic proteins as well as impairments in the performance of tasks designed to assess spatial learning and episodic memory .
In this rodent study the effects of different time periods ( ranging from 2 weeks to 6 months ) of oral treatment with the FGA , haloperidol ( 2.0 mg / kg / day ) , or the SGA , risperidone ( 2.5 mg / kg / day ) on a water maze repeated acquisition procedure , the levels of nerve growth factor receptors , and two important cholinergic proteins , the vesicular acetylcholine transporter and the high affinity choline transporter were evaluated .
Oral haloperidol or risperidone treatment in rats : temporal effects on nerve growth factor receptors , cholinergic neurons , and memory performance .
Further , haloperidol was associated with decrements in short delay performance in the spontaneous novel object recognition task during both the 8 - 14 and 31 - 38 day periods of treatment , while risperidone was associated with short delay impairment during the 31 - 38 day time period .
In this rodent study the effects of different time periods ( ranging from 2 weeks to 6 months ) of oral treatment with the FGA , haloperidol ( 2.0 mg / kg / day ) , or the SGA , risperidone ( 2.5 mg / kg / day ) on a water maze repeated acquisition procedure , the levels of nerve growth factor receptors , and two important cholinergic proteins , the vesicular acetylcholine transporter and the high affinity choline transporter were evaluated .
Haloperidol ( but not risperidone ) was associated with impairments in water maze hidden platform trial performance at each of the time periods evaluated up to 45 days , but not when tested during days 83 - 90 .
These data from rats support the notion that while risperidone may hold some advantages over haloperidol , both antipsychotics can produce time - dependent alterations in neurotrophin receptors and cholinergic proteins as well as impairments in the performance of tasks designed to assess spatial learning and episodic memory .
These data from rats support the notion that while risperidone may hold some advantages over haloperidol , both antipsychotics can produce time - dependent alterations in neurotrophin receptors and cholinergic proteins as well as impairments in the performance of tasks designed to assess spatial learning and episodic memory .
These data from rats support the notion that while risperidone may hold some advantages over haloperidol , both antipsychotics can produce time - dependent alterations in neurotrophin receptors and cholinergic proteins as well as impairments in the performance of tasks designed to assess spatial learning and episodic memory .
These data from rats support the notion that while risperidone may hold some advantages over haloperidol , both antipsychotics can produce time - dependent alterations in neurotrophin receptors and cholinergic proteins as well as impairments in the performance of tasks designed to assess spatial learning and episodic memory .
These data from rats support the notion that while risperidone may hold some advantages over haloperidol , both antipsychotics can produce time - dependent alterations in neurotrophin receptors and cholinergic proteins as well as impairments in the performance of tasks designed to assess spatial learning and episodic memory .
First and second generation antipsychotics ( FGAs and SGAs ) ameliorate psychotic symptoms of schizophrenia , however , their chronic effects on information processing and memory function ( i.e. key determinants of long term functional outcome ) are largely unknown .
First and second generation antipsychotics ( FGAs and SGAs ) ameliorate psychotic symptoms of schizophrenia , however , their chronic effects on information processing and memory function ( i.e. key determinants of long term functional outcome ) are largely unknown .
First and second generation antipsychotics ( FGAs and SGAs ) ameliorate psychotic symptoms of schizophrenia , however , their chronic effects on information processing and memory function ( i.e. key determinants of long term functional outcome ) are largely unknown .
First and second generation antipsychotics ( FGAs and SGAs ) ameliorate psychotic symptoms of schizophrenia , however , their chronic effects on information processing and memory function ( i.e. key determinants of long term functional outcome ) are largely unknown .
First and second generation antipsychotics ( FGAs and SGAs ) ameliorate psychotic symptoms of schizophrenia , however , their chronic effects on information processing and memory function ( i.e. key determinants of long term functional outcome ) are largely unknown .
First and second generation antipsychotics ( FGAs and SGAs ) ameliorate psychotic symptoms of schizophrenia , however , their chronic effects on information processing and memory function ( i.e. key determinants of long term functional outcome ) are largely unknown .
These data from rats support the notion that while risperidone may hold some advantages over haloperidol , both antipsychotics can produce time - dependent alterations in neurotrophin receptors and cholinergic proteins as well as impairments in the performance of tasks designed to assess spatial learning and episodic memory .
These data from rats support the notion that while risperidone may hold some advantages over haloperidol , both antipsychotics can produce time - dependent alterations in neurotrophin receptors and cholinergic proteins as well as impairments in the performance of tasks designed to assess spatial learning and episodic memory .
These data from rats support the notion that while risperidone may hold some advantages over haloperidol , both antipsychotics can produce time - dependent alterations in neurotrophin receptors and cholinergic proteins as well as impairments in the performance of tasks designed to assess spatial learning and episodic memory .
These data from rats support the notion that while risperidone may hold some advantages over haloperidol , both antipsychotics can produce time - dependent alterations in neurotrophin receptors and cholinergic proteins as well as impairments in the performance of tasks designed to assess spatial learning and episodic memory .
These data from rats support the notion that while risperidone may hold some advantages over haloperidol , both antipsychotics can produce time - dependent alterations in neurotrophin receptors and cholinergic proteins as well as impairments in the performance of tasks designed to assess spatial learning and episodic memory .
These data from rats support the notion that while risperidone may hold some advantages over haloperidol , both antipsychotics can produce time - dependent alterations in neurotrophin receptors and cholinergic proteins as well as impairments in the performance of tasks designed to assess spatial learning and episodic memory .
These data from rats support the notion that while risperidone may hold some advantages over haloperidol , both antipsychotics can produce time - dependent alterations in neurotrophin receptors and cholinergic proteins as well as impairments in the performance of tasks designed to assess spatial learning and episodic memory .
These data from rats support the notion that while risperidone may hold some advantages over haloperidol , both antipsychotics can produce time - dependent alterations in neurotrophin receptors and cholinergic proteins as well as impairments in the performance of tasks designed to assess spatial learning and episodic memory .
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