Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans.

@article{Cai2014OralGA,
  title={Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans.},
  author={Weijing Cai and Jaime Uribarri and Li Zhu and Xue Chen and Shobha M Swamy and Zhengshan Zhao and Fabrizio Grosjean and Calogera M. Simonaro and George A Kuchel and Michal Schnaider-Beeri and Mark Woodward and Gary E. Striker and Helen Vlassara},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 13},
  pages={4940-5}
}
Age-associated dementia and Alzheimer's disease (AD) are currently epidemic. Neither their cause nor connection to the metabolic syndrome (MS) is clear. Suppression of deacetylase survival factor sirtuin 1 (SIRT1), a key host defense, is a central feature of AD. Age-related MS and diabetes are also causally associated with suppressed SIRT1 partly due to oxidant glycotoxins [advanced glycation end products (AGEs)]. Changes in the modern diet include excessive nutrient-bound AGEs, such as… CONTINUE READING
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