Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial.

@article{Daniele2001OralGI,
  title={Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial.},
  author={Bruno Daniele and Francine Perrone and C{\'e}sar Gallo and Sandro Pignata and Salvatore De Martino and Rocco De Vivo and Ermanno Barletta and Rosa Tambaro and Roberto Andrea Abbiati and Luciano D'Agostino},
  journal={Gut},
  year={2001},
  volume={48 1},
  pages={28-33}
}
BACKGROUND 5-Fluorouracil (FU) in association with folinic acid (FA) is the most frequently used chemotherapeutic agent in colorectal cancer but it often causes diarrhoea. Animal and human studies suggest that glutamine stimulates intestinal mucosal growth. AIM To determine if oral glutamine prevents changes in intestinal absorption (IA) and permeability (IP) induced by FU/FA. METHODS Seventy chemotherapy naive patients with colorectal cancer were randomly assigned to oral glutamine (18 g… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS
36 Citations
37 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 37 references

5 - fluorouracil and folinic acidinducd mucositis : no e V ect of oral glutamine supplementation

  • SA Jebb, RJ Osborne, TS Maughan
  • Br J Cancer
  • 1994

Similar Papers

Loading similar papers…