Oral gel loaded with penciclovir–lavender oil nanoemulsion to enhance bioavailability and alleviate pain associated with herpes labialis

  title={Oral gel loaded with penciclovir–lavender oil nanoemulsion to enhance bioavailability and alleviate pain associated with herpes labialis},
  author={Khaled Mohamed Hosny and Amal M. Sindi and Hala M. Alkhalidi and Mallesh Kurakula and Nabil K Alruwaili and Nabil Abdulhafiz Alhakamy and Walaa A. Abualsunun and Rana B Bakhaidar and Rahaf H. Bahmdan and Waleed Y Rizg and Sarah A. Ali and Wesam H. Abdulaal and Majed S Nassar and Mohammed S. Alsuabeyl and Adel F. Alghaith and Sultan M Alshehri},
  journal={Drug Delivery},
  pages={1043 - 1054}
Abstract Herpes labialis, caused by herpes simplex virus type 1, is usually characterized by painful skin or mucosal lesions. Penciclovir (PV) tablets are found to be effective against herpes labialis but suffer from poor oral bioavailability. This study aimed to combine the benefits of PV and lavender oil (LO), which exhibits anesthetic activity, in the form of a self-nanoemulsifying drug delivery system (SNEDDS) for the treatment of herpes labialis. Toward this purpose, LO (oil), Labrasol… Expand
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