Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study.

@article{Boyles2009OralFC,
  title={Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study.},
  author={Abee Lowman Boyles and Allen J Wilcox and Jack A. Taylor and Min Shi and Clarice R. Weinberg and Klaus Meyer and {\AA}se Fredriksen and Per Magne Ueland and Anne Marte Wetting Johansen and Christian A. Drevon and Astanand Jugessur and Truc Nguyen Trung and H{\aa}kon Kristian Gjessing and Stein Emil Vollset and Jeffrey C. Murray and Kaare Christensen and Rolv T. Lie},
  journal={Genetic epidemiology},
  year={2009},
  volume={33 3},
  pages={
          247-55
        }
}
An increased risk of facial clefts has been observed among mothers with lower intake of folic acid or vitamin A around conception. We hypothesized that the risk of clefts may be further moderated by genes involved in metabolizing folate or vitamin A. We included 425 case-parent triads in which the child had either cleft lip with or without cleft palate (CL/P) or cleft palate only (CPO), and no other major defects. We analyzed 108 SNPs and one insertion in 29 genes involved in folate/one-carbon… CONTINUE READING

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CBS c.844ins68 Polymorphism Frequencies in Control Populations: Implications on Nonsyndromic Cleft Lip with or without Cleft Palate

  • The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
  • 2015

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