Oral facial clefts and gene polymorphisms in metabolism of folate/one‐carbon and vitamin A: a pathway‐wide association study

@article{Boyles2009OralFC,
  title={Oral facial clefts and gene polymorphisms in metabolism of folate/one‐carbon and vitamin A: a pathway‐wide association study},
  author={A. Boyles and A. Wilcox and J. Taylor and M. Shi and C. Weinberg and K. Meyer and {\AA}. Fredriksen and P. Ueland and A. M. W. Johansen and C. Drevon and A. Jugessur and T. N. Trung and H. Gjessing and S. Vollset and J. Murray and K. Christensen and R. T. Lie},
  journal={Genetic Epidemiology},
  year={2009},
  volume={33}
}
An increased risk of facial clefts has been observed among mothers with lower intake of folic acid or vitamin A around conception. We hypothesized that the risk of clefts may be further moderated by genes involved in metabolizing folate or vitamin A. We included 425 case‐parent triads in which the child had either cleft lip with or without cleft palate (CL/P) or cleft palate only (CPO), and no other major defects. We analyzed 108 SNPs and one insertion in 29 genes involved in folate/one‐carbon… Expand
54 Citations
Folate pathway and nonsyndromic cleft lip and palate.
  • 82
Sequence variation in folate pathway genes and risks of human cleft lip with or without cleft palate
  • 14
Evaluation of proton‐coupled folate transporter (SLC46A1) polymorphisms as risk factors for neural tube defects and oral clefts
  • 6
Genetic Determinants of Facial Clefting: Analysis of 357 Candidate Genes Using Two National Cleft Studies from Scandinavia
  • 96
BHMT gene polymorphisms as risk factors for cleft lip and cleft palate in a Chinese population.
  • 15
  • PDF
Thymidylate synthase polymorphisms and risks of human orofacial clefts.
  • G. Shaw, W. Yang, +4 authors E. Lammer
  • Biology, Medicine
  • Birth defects research. Part A, Clinical and molecular teratology
  • 2013
  • 7
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 45 REFERENCES
Folate and one‐carbon metabolism gene polymorphisms and their associations with oral facial clefts
  • 70
  • PDF
Fetal and maternal MTHFR C677T genotype, maternal folate intake and the risk of nonsyndromic oral clefts
  • 79
  • Highly Influential
Cystathionine beta‐synthase c.844ins68 gene variant and non‐syndromic cleft lip and palate
  • 36
Maternal MTR genotype contributes to the risk of non‐syndromic cleft lip and palate in the Polish population
  • 85
Study of folate receptor genes in nonsyndromic familial and sporadic cleft lip with or without clef palate cases
  • 16
...
1
2
3
4
5
...