Oral erdosteine administration attenuates cisplatin-induced renal tubular damage in rats.

@article{Yildirim2003OralEA,
  title={Oral erdosteine administration attenuates cisplatin-induced renal tubular damage in rats.},
  author={Zeki Yildirim and Sadik Sogut and Ersan Odaci and Mustafa Iraz and H{\"u}seyin Ozyurt and Mahir Kotuk and Omer Akyol},
  journal={Pharmacological research},
  year={2003},
  volume={47 2},
  pages={149-56}
}
The effect of oral erdosteine on tissue malondialdehyde (MDA) and nitric oxide (NO) levels, and catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities are investigated in the cisplatin model of acute renal failure in rats. A single dose of cisplatin caused kidney damage manifested by kidney histology as well as increases in plasma creatinine and blood urea nitrogen (BUN) levels. Treatment with free radical scavenger erdosteine attenuated increases in plasma… CONTINUE READING