Oral epithelium as a surrogate tissue for assessing smoking-induced molecular alterations in the lungs.

@article{Bhutani2008OralEA,
  title={Oral epithelium as a surrogate tissue for assessing smoking-induced molecular alterations in the lungs.},
  author={Manisha Bhutani and Ashutosh K. Pathak and Y Fan and Diane D. Liu and J Jack Lee and Hongli Tang and Jonathan M. Kurie and Rodolfo C. Morice and Edward S. Kim and Waun Ki Hong and Li Mao},
  journal={Cancer prevention research},
  year={2008},
  volume={1 1},
  pages={39-44}
}
The lungs and oral cavity of smokers are exposed to tobacco carcinogens. We hypothesized that tobacco-induced molecular alterations in the oral epithelium are similar to those in the lungs, and thus the oral epithelium may be used as a surrogate tissue for assessing alterations in the lungs. We used methylation-specific PCR to analyze promoter methylation of the p16 and FHIT genes at baseline and 3 months after intervention in 1,774 oral and bronchial brush specimens from 127 smokers enrolled… CONTINUE READING
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