Oral effects of low-dose methotrexate treatment.

  title={Oral effects of low-dose methotrexate treatment.},
  author={Athanasios Kalantzis and Zoe Marshman and Denis T Falconer and Peter Roger Morgan and E. W. Odell},
  journal={Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics},
  volume={100 1},
Methotrexate is used increasingly in low-dose regimes for a variety of conditions, particularly rheumatoid arthritis. While certain adverse effects of low-dose methotrexate have been described in detail, oral complications have received little attention. This article includes a summary of the uses and pharmacology of low-dose methotrexate and the mechanisms that lead to general and oral toxicity. The literature relevant to potential oral adverse effects is discussed and 7 illustrative cases are… CONTINUE READING

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