Oral dyskinesias and histopathological alterations in substantia nigra after long-term haloperidol treatment of old rats.

@article{Andreassen2003OralDA,
  title={Oral dyskinesias and histopathological alterations in substantia nigra after long-term haloperidol treatment of old rats.},
  author={Ole A. Andreassen and Robert Ferrante and Trond Oskar Aamo and Michael Beal and Hugo Arild J\orgensen},
  journal={Neuroscience},
  year={2003},
  volume={122 3},
  pages={717-25}
}
The pathophysiologic basis of tardive dyskinesia remains unclear, but several lines of evidence suggest that persistent neuronal changes in the basal ganglia produced by oxidative stress or glutamate toxicity may play a role, especially in the elderly. In the present study we examined whether histopathological alterations in substantia nigra are related to oral dyskinesia in a rodent model of tardive dyskinesia. Haloperidol decanoate (38 mg/kg/4 weeks) was administered to young (8 weeks) and… CONTINUE READING

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