Oral disinfectants inhibit protein-protein interactions mediated by the anti-apoptotic protein Bcl-xL and induce apoptosis in human oral tumor cells.

@article{Grber2013OralDI,
  title={Oral disinfectants inhibit protein-protein interactions mediated by the anti-apoptotic protein Bcl-xL and induce apoptosis in human oral tumor cells.},
  author={Martin Gr{\"a}ber and Michael Hell and Corinna Gr{\"o}st and Anders Friberg and Bianca Sperl and Michael Sattler and Thorsten Berg},
  journal={Angewandte Chemie},
  year={2013},
  volume={52 16},
  pages={4487-91}
}
Significant advances during the last decade in the field of small-molecule modulators of protein–protein interactions have raised general awareness of the fact that the modulation of protein–protein interactions has tremendous potential for both basic and applied science. Some of the most advanced orthosteric inhibitors of protein–protein interactions are currently in clinical trials. Here, we demonstrate that the bisbiguanide oral disinfectants chlorhexidine (the active ingredient of… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-2 of 2 references

Anti-Cancer Agents Med

  • C. Mas-Moruno, F. Rechenmacher, H. Kessler
  • Chem. 2010,
  • 2010
1 Excerpt

The PyMOL Molecular Graphics System

  • W. L. DeLano
  • DeLano Scientific,
  • 2002
1 Excerpt

Similar Papers

Loading similar papers…