Oral delivery of nanoparticles containing anticancer SN38 and hSET1 antisense for dual therapy of colon cancer.

@article{Dinarvand2015OralDO,
  title={Oral delivery of nanoparticles containing anticancer SN38 and hSET1 antisense for dual therapy of colon cancer.},
  author={Meshkat Dinarvand and Melika Kiani and F Mirzazadeh and Arash Esmaeili and Zahra Hadavand Mirzaie and Masoud Soleimani and Rassoul Dinarvand and Fatemeh Atyabi},
  journal={International journal of biological macromolecules},
  year={2015},
  volume={78},
  pages={112-21}
}
An oral delivery system intended for treatment of colon cancer in HT29 cancerous cells was investigated by encapsulating hSET1 antisense and SN38 anticancer in nanoparticles based on cysteine trimethyl chitosan (cysTMC) and carboxymethyl dextran (CMD). Studies have shown hSET1 as the main type of histone methyltransferase (HMT) complex, is significantly overexpressed in malignant cells. In this study, hSET1 antisense was employed to inhibit gene expression. Additionally, SN38 was incorporated… CONTINUE READING

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