Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge.

  title={Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge.},
  author={P. J. Rice and Elizabeth L Adams and Tammy R Ozment-Skelton and Andr{\'e}s J. Gonzalez and Matthew P Goldman and Brent E Lockhart and Luke A Barker and Kevin F. Breuel and Warren K Deponti and John H. Kalbfleisch and Harry E. Ensley and Gordon D Brown and Siamon Gordon and David L Williams},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={314 3},
Glucans are immunomodulatory carbohydrates found in the cell walls of fungi and certain bacteria. We examined the pharmacokinetics of three water-soluble glucans (glucan phosphate, laminarin, and scleroglucan) after oral administration of 1 mg/kg doses in rats. Maximum plasma concentrations for glucan phosphate occurred at 4 h. In contrast, laminarin and scleroglucan showed two plasma peaks between 0.5 and 12 h. At 24 h, 27 +/- 3% of the glucan phosphate and 20 +/- 7% of the laminarin remained… CONTINUE READING


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