Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge.

@article{Rice2005OralDA,
  title={Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge.},
  author={P. J. Rice and Elizabeth L Adams and Tammy R Ozment-Skelton and Andr{\'e}s J. Gonzalez and Matthew P Goldman and Brent E Lockhart and Luke A Barker and Kevin F. Breuel and Warren K Deponti and John H. Kalbfleisch and Harry E. Ensley and Gordon D Brown and Siamon Gordon and David L Williams},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2005},
  volume={314 3},
  pages={1079-86}
}
Glucans are immunomodulatory carbohydrates found in the cell walls of fungi and certain bacteria. We examined the pharmacokinetics of three water-soluble glucans (glucan phosphate, laminarin, and scleroglucan) after oral administration of 1 mg/kg doses in rats. Maximum plasma concentrations for glucan phosphate occurred at 4 h. In contrast, laminarin and scleroglucan showed two plasma peaks between 0.5 and 12 h. At 24 h, 27 +/- 3% of the glucan phosphate and 20 +/- 7% of the laminarin remained… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 106 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

The influence of glucan polymer structure and solution conformation on binding to (133)- -D-glucan receptors in a human monocyte-like cell line

A Mueller, J Raptis, +5 authors DL Williams
Glycobiology • 2000
View 7 Excerpts
Highly Influenced

High beta-glucan oat bran and oat gum reduce postprandial blood glucose and insulin in subjects with and without type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association • 1994
View 13 Excerpts
Highly Influenced

Effect of orally administered beta-glucan on macrophage function in mice.

International journal of immunopharmacology • 1990
View 6 Excerpts
Highly Influenced

Serum glucan levels are not specific for presence of fungal infections in intensive care unit patients.

Clinical and diagnostic laboratory immunology • 2003
View 6 Excerpts
Highly Influenced

The role of viscous soluble fiber in the metabolic control of diabetes: a review with special emphasis on cereals rich in beta-glucan. Diabetes Care 20:1774–1780

P Wuersch, FX Pi-Sunyer
1997
View 4 Excerpts
Highly Influenced

Development of natural product (133)-beta-Dglucan polymers as immune-stimulating pharmaceuticals

DL Williams, IW Browder
Polymers Adv Technol • 1994
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…