Oral cytokine gene therapy against murine tumor using attenuated Salmonella typhimurium.

@article{Yuhua2001OralCG,
  title={Oral cytokine gene therapy against murine tumor using attenuated Salmonella typhimurium.},
  author={Liao Yuhua and Guo Kunyuan and Chang Guo Hui and Xiang Yongmei and Sun Chaoyang and Tang Xun and Ren Daming},
  journal={International journal of cancer},
  year={2001},
  volume={94 3},
  pages={
          438-43
        }
}
An attenuated strain of Salmonella typhimurium was used as a vehicle for oral gene therapy against murine tumor. Eukaryotic expression vectors containing genes of human interleukin-12 (hIL-12), human granulocyte/macrophage colony-stimulating factor (hGM-CSF), mouse (m)IL-12, mGM-CSF and green fluorescent protein (GFP) were used to transform attenuated Salmonella (SL3261), and such transformants were administered orally to BALB/c and C57BL/6 mice. As a reporter gene, GFP expression in murine… CONTINUE READING
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