Oral contraceptives, reproductive history and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition

Abstract

Background:Oral contraceptive use and reproductive factors may initiate long-term changes to the hormonal milieu and thereby, possibly influence colorectal cancer risk.Methods:We examined the association of hormonal and reproductive factors with risk of colorectal cancer among 337 802 women in the European Prospective Investigation into Cancer and Nutrition, of whom 1878 developed colorectal cancer.Results:After stratification for center and age, and adjustment for body mass index, smoking, diabetes mellitus, physical activity and alcohol consumption, ever use of oral contraceptives was marginally inversely associated with colorectal cancer risk (hazard ratio (HR), 0.92; 95% confidence interval (CI), 0.83–1.02), although this association was stronger among post-menopausal women (HR, 0.84; 95% CI: 0.74–0.95). Duration of oral contraceptive use and reproductive factors, including age at menarche, age at menopause, type of menopause, ever having an abortion, parity, age at first full-term pregnancy and breastfeeding, were not associated with colorectal cancer risk.Conclusion:Our findings provide limited support for a potential inverse association between oral contraceptives and colorectal cancer risk.

DOI: 10.1038/sj.bjc.6605965

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@inproceedings{Tsilidis2010OralCR, title={Oral contraceptives, reproductive history and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition}, author={Konstantinos K. Tsilidis and Naomi E. Allen and Timothy J.A. Key and Kjersti Bakken and Eiliv Lund and Franco Berrino and Agn{\'e}s Fournier and Anja Weinreich Olsen and Anne Marie Tj\onneland and Kim Overvad and M-C Boutron-Ruault and Francoise Clavel-Chapelon and Graham Byrnes and V{\'e}ronique Chaj{\`e}s and Sabina Rinaldi and Jenny Chang-Claude and Rudolf Kaaks and M. Bergmann and H. Boeing and Yvoni Koumantaki and G Stasinopoulou and Antonia Trichopoulou and Domenico Palli and Giovanna Tagliabue and Salvatore Panico and Rosario Tumino and Paolo Vineis and HB Bueno-de-Mesquita and Fr{\"a}nzel J B van Duijnhoven and Carla H van Gils and P. H. M. Peeters and Luis F. Rodriguez and C . A . Gonz{\'a}lez and Mar{\'i}a Jos{\'e} Gonz{\'a}lez S{\'a}nchez and M . D . Chirlaque and Aurelio Barricarte and Miren Dorronsoro and Signe Borgquist and Jonas Manjer and Bethany Van Guelpen and G{\"{o}ran Hallmans and Simon Rodwell and Kay-Tee Khaw and Teresa Norat and Dora Romaguera and Elio Riboli}, booktitle={British Journal of Cancer}, year={2010} }