Oral contraceptives: safety factors in prolonged use of progestin-estrogen combinations. 2.

Some of the changes induced by long-term use of oral contraceptive (OC) preparations are reviewed. It is likely that OCs exert their contraceptive effect by suppressing the midcycle surge of luteinizing hormone; ovarian activity thereby becomes quiescent. There is no firm evidence that OCs alter thyroid or adrenal function. There is also no direct evidence… (More)