Oral contraceptive use and risk of early-onset breast cancer in carriers and noncarriers of BRCA1 and BRCA2 mutations.

@article{Milne2005OralCU,
  title={Oral contraceptive use and risk of early-onset breast cancer in carriers and noncarriers of BRCA1 and BRCA2 mutations.},
  author={Roger L Milne and Julia A Knight and Esther M John and Gillian S. Dite and Ronald Balbuena and Argyrios Ziogas and Irene L Andrulis and Donald W. West and Frederick Li and Melissa C. Southey and Graham G. Giles and Margaret R. E. McCredie and John L Hopper and Alice S. Whittemore},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2005},
  volume={14 2},
  pages={
          350-6
        }
}
BACKGROUND Recent oral contraceptive use has been associated with a small increase in breast cancer risk and a substantial decrease in ovarian cancer risk. The effects on risks for women with germ line mutations in BRCA1 or BRCA2 are unclear. METHODS Subjects were population-based samples of Caucasian women that comprised 1,156 incident cases of invasive breast cancer diagnosed before age 40 (including 47 BRCA1 and 36 BRCA2 mutation carriers) and 815 controls from the San Francisco Bay area… CONTINUE READING

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