Oral contraceptive administration aggravates nitric oxide synthesis inhibition-induced high blood pressure in female rats.

@article{Olatunji2008OralCA,
  title={Oral contraceptive administration aggravates nitric oxide synthesis inhibition-induced high blood pressure in female rats.},
  author={Lawrence Aderemi Olatunji and Ayodele Olufemi Soladoye},
  journal={Pathophysiology : the official journal of the International Society for Pathophysiology},
  year={2008},
  volume={15 4},
  pages={221-6}
}
UNLABELLED The use of estrogen-progestogen oral contraceptive (OC) is associated with high blood pressure, although mechanisms responsible are still unclear. This study sought to investigate the effects of administration of OC on high blood pressure resulting from nitric oxide (NO) synthesis inhibition in female Sprague-Dawley rats. Rats were given ethinyl estradiol in combination with norgestrel and were treated with NO synthase inhibitor, N(G)-nitro-l-arginine methyl ester (l-NAME) in the… CONTINUE READING