Oral cobalamin (vitamin B12) treatment. An update

@article{Andrs2009OralC,
  title={Oral cobalamin (vitamin B12) treatment. An update},
  author={E. Andr{\`e}s and N. Dali-Youcef and T. Vogel and K. Serraj and J. Zimmer},
  journal={International Journal of Laboratory Hematology},
  year={2009},
  volume={31}
}
The objective of this review was to evaluate oral cobalamin (vitamin B12) therapy in adult and elderly patients, from the perspective of a hematologist. PubMed was systematically searched for English and French articles published from January 1990 to January 2007. Data from our working group, the ‘Groupe d’étude des carences en vitamine B12des Hôpitaux Universitaires de Strasbourg’, have also been included. Several prospective studies in well‐determined population (n = 4), prospective… Expand

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TLDR
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TLDR
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B12 and Folic Acid
Vitamin B12 deficiency is common in older adults and predisposed to by several factors including inadequate diet, food-cobalamin malabsorption, a host of gastric and small intestinal disorders, andExpand
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References

SHOWING 1-10 OF 41 REFERENCES
[Early response to oral cobalamin therapy in older patients with vitamin B12 deficiency].
TLDR
The findings suggest that cyanocobalamin given orally during one week may be an effective treatment for cobalamin deficiency related to food-cobalamin malabsorption and nutritional deficiency and may avoid painful intra-muscular injections in older patients. Expand
Treatment of Vitamin B12–Deficiency Anemia: Oral versus Parenteral Therapy
TLDR
There are inadequate data at the present time to support the use of oral cyanocobalamin replacement in patients with severe neurologic involvement, and several studies provide evidence that daily oral cyanOCobalamin as opposed to monthly parenteral formulations may adequately treat both types of cobalamin-deficient anemias. Expand
Hematological response to short-term oral cyanocobalamin therapy for the treatment of cobalamin deficiencies in elderly patients.
TLDR
The view that one month of oral crystalline cyanocobalamin is effective to correct serum vitamin B12 levels and to obtain hematological responses in elderly patients with cobalamin deficiency related to food-cobalamin malabsorption (FCM) is supported. Expand
Oral versus intramuscular cobalamin treatment in megaloblastic anemia: a single-center, prospective, randomized, open-label study.
TLDR
In this study of patients with megaloblastic anemia due to cobalamin deficiency, p.o. Cobalamin treatment was as effective as i.m. cobalamine treatment and better tolerated and less expensive compared with IM treatment. Expand
Efficacy of short-term oral cobalamin therapy for the treatment of cobalamin deficiencies related to food-cobalamin malabsorption: a study of 30 patients.
TLDR
Crystalline cyanocobalamin, 250-1000 microg/day, given orally for 1 month, may be an effective treatment for cobalamin deficiencies not related to pernicious anemia. Expand
Oral cobalamin therapy for the treatment of patients with food-cobalamin malabsorption.
TLDR
The findings suggest that moderate doses of crystalline cyanocobalamin given orally may be an effective treatment for food-cobalamin malabsorption. Expand
Effective treatment of cobalamin deficiency with oral cobalamin.
TLDR
In cobalamin deficiency, 2 mg of cyanocobalamin administered orally on a daily basis was as effective as 1 mg administered intramuscularly on a monthly basis and may be superior. Expand
Oral cobalamin remains medicine's best kept secret.
TLDR
Strategies to promote the use of oral cobalamin should be directed at educating physicians of its efficacy and providing them with prescribing information on where it can be purchased. Expand
Food-cobalamin malabsorption in elderly patients: clinical manifestations and treatment.
TLDR
It is suggested that in elderly patients, FCM may be associated with significant neurologic, psychologic, and hematologic abnormalities, which seem to respond equally well to either oral or parenteral vitamin B12 therapy. Expand
Food cobalamin malabsorption: a usual cause of vitamin B12 deficiency.
TLDR
It is confirmed that food cobalamin malabsorption was emerging as a major cause of vitamin B12 deficiency and pernicious anemia was a rare condition. Expand
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