Oral cholic acid for hereditary defects of primary bile acid synthesis: a safe and effective long-term therapy.

BACKGROUND & AIMS Oral bile acid replacement has been shown to be an effective therapy in primary bile acid synthesis defects, but to date there have been no reports of the long-term effects of this therapy. The aim of the study was to evaluate the long-term effectiveness and safety of cholic acid (CA) therapy. METHODS Fifteen patients with either 3beta… CONTINUE READING