Oral cancer prevention: the case for carotenoids and anti-oxidant nutrients.

  title={Oral cancer prevention: the case for carotenoids and anti-oxidant nutrients.},
  author={Harinder S. Garewal and Frank L. jr. Meyskens and Shelly Friedman and David S. Alberts and Lois Ramsey},
  journal={Preventive medicine},
  volume={22 5},
The most convincing evidence for a preventive role for any modality is obviously demonstration of incidence reduction produced by that modality. However, cancer prevention trials with cancer incidence as an endpoint have logistic problems rendering them essentially impossible to conduct for most malignancies. Hence a workable strategy often involves analysis of other, indirect lines of evidence to reach conclusions. For oral cancer, dietary epidemiologic evidence points to a protective role for… 

Dietary Cancer Chemoprevention: An Overview

A new paradigm for diet, nutrient and cancer prevention can be developed using a multidisciplinary approach that includes lifestyle and environmental changes, dietary modification and physical activities consciousness to reduce the burden of cancer.

Dietary Control of Cancer

  • K. El-BayoumyF. Chung E. Wynder
  • Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1997
The evidence from epidemiological, mechanistic, and preclinical efficacy studies indicating a protective effect of micronutrients, non-nutrients, and certain antioxidants in food against oral and lung cancers is discussed.

Bionutrition and oral cancer in humans.

  • C. EnwonwuV. Meeks
  • Medicine, Biology
    Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists
  • 1995
This review article underscores the compounding but important roles of nutritional/dietary factors in the long-established causal link between abuse of alcohol and tobacco (smoking and smokeless) and oral cancer.

Dietary modifiers of carcinogenesis.

Dietary components express a wide range of activities that can affect carcinogenesis, and potential anticarcinogens such as the carotenoids, tocopherols, phenolic compounds, glucosinolates, metal-binding proteins, phytoestrogens, and conjugated linoleic acid are discussed.

Retinoid actions and implications for prevention and therapy of oral cancer.

  • S. GirodM. Pfahl
  • Medicine
    International journal of oral and maxillofacial surgery
  • 1996

Cancer Chemoprevention

  • S. Rosen
  • Medicine, Biology
    Cancer Treatment and Research
  • 2001
The promise of this overall strategy is the ability to conduct faster, smaller and more cost effective trials which incorporate validated surrogate endpoints rather than conventional clinical endpoints (cancer incidence, recurrence and survival).

Treatment of oral leukoplakia with a low‐dose of beta‐carotene and vitamin C supplements: A randomized controlled trial

Data from this RCT does not support the hypothesis that chemoprevention with this treatment is effective for oral leukoplakia, and beta‐carotene (10 mg day−1) and vitamin C were neither effective for clinical remission, nor for protection against the development of cancer.

Lutein Treatment Effects on the Redox Status and Metalloproteinase-9 (MMP-9) in Oral Cancer Squamous Cells—Are There Therapeutical Hopes?

Loaded in Nps, lutein could be regarded as a protective factor against local invasiveness, in whose molecular landscape MMPs, and especially MMP-9 are the main actors.

Blood Iron, Glutathione, and Micronutrient Levels and the Risk of Oral Cancer

It is suggested that mild iron deficiency and low GSH levels, which are associated with increased oxidative stress, increase the risk of oral cavity cancer.

Randomized double-blind trial of beta-carotene and vitamin C in women with minor cervical abnormalities

High doses of these compounds are unlikely to increase the regression or decrease the progression of minor atypia and CIN I, and there was some evidence of an interaction effect of the two compounds on the progression rate.