Oral cadmium chloride intoxication in mice: effects of penicillamine, dimercaptosuccinic acid and related compounds.

@article{Andersen1988OralCC,
  title={Oral cadmium chloride intoxication in mice: effects of penicillamine, dimercaptosuccinic acid and related compounds.},
  author={Ole Bj\orn Andersen and Jesper Bo Nielsen},
  journal={Pharmacology & toxicology},
  year={1988},
  volume={63 5},
  pages={386-9}
}
The antidotal efficacies of chelators during acute cadmium intoxication has previously been examined in experiments where both a soluble cadmium salt and the chelator were administered parenterally. In the present study, PA, DMSA and related compounds were studied as oral antidotes during oral CdCl2 intoxication. According to the antagonistic effects noted on mortality, peristaltic toxicity and intestinal cadmium uptake, the relative efficacies of the compounds tested were: DMSA greater than… CONTINUE READING