Oral budesonide for active Crohn's disease. Canadian Inflammatory Bowel Disease Study Group.

@article{Greenberg1994OralBF,
  title={Oral budesonide for active Crohn's disease. Canadian Inflammatory Bowel Disease Study Group.},
  author={Gordon R. Greenberg and Brian G Feagan and François Martin and Lloyd R. Sutherland and Alan B. R. Thomson and Cynthia Williams and Lars G{\"o}ran Nilsson and Tore Persson},
  journal={The New England journal of medicine},
  year={1994},
  volume={331 13},
  pages={836-41}
}
BACKGROUND Corticosteroids are the most efficacious drugs for inducing remission in active Crohn's disease, but their benefits are frequently offset by serious side effects. Budesonide is a corticosteroid with high topical antiinflammatory activity but low systemic activity because of extensive hepatic metabolism. We investigated the efficacy and safety of an oral controlled-ileal-release preparation of budesonide in patients with active Crohn's disease involving the ileum or ileum and proximal… CONTINUE READING
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