Oral branched-chain amino acid supplements that reduce brain serotonin during exercise in rats also lower brain catecholamines

@article{Choi2013OralBA,
  title={Oral branched-chain amino acid supplements that reduce brain serotonin during exercise in rats also lower brain catecholamines},
  author={Sujean Choi and B. Disilvio and Madelyn H. Fernstrom and John D. Fernstrom},
  journal={Amino Acids},
  year={2013},
  volume={45},
  pages={1133-1142}
}
Exercise raises brain serotonin release and is postulated to cause fatigue in athletes; ingestion of branched-chain amino acids (BCAA), by competitively inhibiting tryptophan transport into brain, lowers brain tryptophan uptake and serotonin synthesis and release in rats, and reputedly in humans prevents exercise-induced increases in serotonin and fatigue. This latter effect in humans is disputed. But BCAA also competitively inhibit tyrosine uptake into brain, and thus catecholamine synthesis… 

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