Oral bone loss is increased in ovariectomized rats.

  title={Oral bone loss is increased in ovariectomized rats.},
  author={James A. Gilles and David Carnes and Mark R. Dallas and Stanley C. Holt and Lynda F. Bonewald},
  journal={Journal of endodontics},
  volume={23 7},
Alveolar bone loss associated with periodontal disease occurs frequently in postmenopausal females, the same group that is predisposed to osteoporosis. To determine if the estrogen-deficient state enhances oral bone loss, we studied ovariectomized rats administered the potent bone-resorbing cytokine interleukin-1 or the periodontal pathogen Campylobacter rectus lipopolysaccharide (LPS). Distal root canals of first mandibular molars were instrumented with endodontic files, and bone resorbing… CONTINUE READING