Oral bioavailability of insulin contained in polysaccharide nanoparticles.

  title={Oral bioavailability of insulin contained in polysaccharide nanoparticles.},
  author={Bruno Sarmento and Ant{\'o}nio Meireles Ribeiro and F. Alte da Veiga and Domingos Ferreira and Ronald Neufeld},
  volume={8 10},
The pharmacological activity of insulin-loaded dextran sulfate/chitosan nanoparticles was evaluated following oral dosage in diabetic rats. Nanoparticles were mucoadhesive and negatively charged with a mean size of 500 nm, suitable for uptake within the gastrointestinal tract. Insulin association efficiency was over 70% and was released in a pH-dependent manner under simulated gastrointestinal conditions. Orally delivered nanoparticles lowered basal serum glucose levels in diabetic rats around… CONTINUE READING
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