Oral bioavailability of insulin contained in polysaccharide nanoparticles.

@article{Sarmento2007OralBO,
  title={Oral bioavailability of insulin contained in polysaccharide nanoparticles.},
  author={Bruno Sarmento and Ant{\'o}nio Meireles Ribeiro and F. Alte da Veiga and Domingos Ferreira and Ronald Neufeld},
  journal={Biomacromolecules},
  year={2007},
  volume={8 10},
  pages={3054-60}
}
The pharmacological activity of insulin-loaded dextran sulfate/chitosan nanoparticles was evaluated following oral dosage in diabetic rats. Nanoparticles were mucoadhesive and negatively charged with a mean size of 500 nm, suitable for uptake within the gastrointestinal tract. Insulin association efficiency was over 70% and was released in a pH-dependent manner under simulated gastrointestinal conditions. Orally delivered nanoparticles lowered basal serum glucose levels in diabetic rats around… CONTINUE READING
57 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 57 extracted citations

Similar Papers

Loading similar papers…