Oral bioavailability of etoposide after administration of a single dose to tumor-bearing dogs.

@article{Flory2008OralBO,
  title={Oral bioavailability of etoposide after administration of a single dose to tumor-bearing dogs.},
  author={Andrea B Flory and Kenneth M. Rassnick and Cheryl E. Balkman and Michael A Kiselow and Karoliina P. M. Autio and Bernard B. Beaulieu and Lionel D Lewis},
  journal={American journal of veterinary research},
  year={2008},
  volume={69 10},
  pages={1316-22}
}
OBJECTIVE To characterize oral bioavailability and pharmacokinetic disposition of etoposide when the IV formulation was administered orally to dogs. ANIMALS 8 tumor-bearing dogs. PROCEDURES An open-label, single-dose, 2-way crossover study was conducted. Dogs were randomly assigned to initially receive a single dose of etoposide (50 mg/m2) IV or PO. A second dose was administered via the alternate route 3 to 7 days later. Medications were administered before IV administration of etoposide… CONTINUE READING