Oral bioavailability enhancement of a hydrophilic drug delivered via folic acid-coupled liposomes in rats.

@article{Ling2009OralBE,
  title={Oral bioavailability enhancement of a hydrophilic drug delivered via folic acid-coupled liposomes in rats.},
  author={Sharon Sheue Nee Ling and Kah Hay Yuen and Enrico Magosso and Susan A Barker},
  journal={The Journal of pharmacy and pharmacology},
  year={2009},
  volume={61 4},
  pages={445-9}
}
OBJECTIVES A liposome preparation that is amenable to receptor-mediated endocytosis has been developed to enhance the oral bioavailability of poorly absorbable peptidomimetic drugs by use of folic acid as the mediator of liposomal uptake. METHODS Folic acid was physically coupled to the surface of the liposomes and cefotaxime was used as the model drug. In-vivo evaluation was carried out on eight Sprague-Dawley rats in a two-way crossover study to compare the oral bioavailability of… CONTINUE READING

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