Oral bioavailability and pharmacokinetics of sildenafil citrate dry foam tablets in rats

  title={Oral bioavailability and pharmacokinetics of sildenafil citrate dry foam tablets in rats},
  author={Somchai Sawatdee and Apichart Atipairin and Attawadee Sae Yoon and T. Srichana and N. Changsan and T. Suwandecha and Wirot Chanthorn and A. N. Phoem},
  journal={Cogent Medicine},
Abstract Sildenafil has low water solubility and oral bioavailability. Dry foam formulations of solid dosage forms of poorly water-soluble drugs may exhibit improved dissolution and bioavailability. We previously developed a sildenafil citrate dry foam tablet formulation and found that it had an improved dissolution profile. In this study, we investigated the pharmacokinetic parameters of sildenafil dry foam tablets in rats after oral administration (at a dose equivalent to 20 mg/kg of… Expand
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