Oral bioavailability and pharmacodynamic activity of hesperetin nanocrystals generated using a novel bottom-up technology.

  title={Oral bioavailability and pharmacodynamic activity of hesperetin nanocrystals generated using a novel bottom-up technology.},
  author={Ganesh Shete and Yogesh B. Pawar and Kaushik Thanki and Sanyog Jain and Arvind Kumar Bansal},
  journal={Molecular pharmaceutics},
  volume={12 4},
In the present study, nanocrystalline solid dispersion (NSD) was developed to enhance the release rate and oral bioavailability of hesperetin (HRN). NSD of HRN was prepared using a novel bottom-up technology platform. It is a spray drying based technology to generate solid particles, containing drug nanocrystals dispersed in small molecule excipients. HRN and mannitol were used in a 5:5 ratio, and an average crystallite size of HRN in NSD with mannitol was found to be 137.3 ± 90.0 nm. An in… 

Eplerenone nanocrystals engineered by controlled crystallization for enhanced oral bioavailability

Acute oral toxicity study showed that EPL-NCs do not pose any toxicity concern to the blood and vital organs, and NCs prepared by controlled crystallization technique present a promising strategy to improve solubility profile, dissolution velocity and bioavailability of poorly water-soluble drugs.

Design of Cilostazol Nanocrystals for Improved Solubility

  • Jin-Seok Choi
  • Materials Science
    Journal of Pharmaceutical Innovation
  • 2019
Purpose The purpose of this study is to achieve enhanced solubility of cilostazol (CLT) by nanocrystal (NC) formation. CLT-NC was prepared by nanoprecipitation without the use of surfactant. Methods

High dose nanocrystalline solid dispersion powder of voriconazole for inhalation.

Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery

Nanotechnology is used to develop a new formulation containing hesperetin (Hst), a substance not previously used in the treatment of chronic venous insufficiency, impregnated into textile fibers as a possible alternative treatment of venous diseases.

Nanocrystals for Delivery of Therapeutic Agents

An overview of formulation, preparation methodologies, stabilization techniques, characterization, evaluation, applications, biopharmaceutical aspects, safety and efficacy, and regulatory perspectives related to nanocrystals is provided.

Optimization of Astaxanthin microencapsulation in hydrophilic carriers using response surface methodology

Quality by Design (QbD) study can form a basis for further development of poorly water soluble AST formulation by oral route with improved bioavailability on larger scale.

Co-delivery of hesperetin enhanced bicalutamide induced apoptosis by exploiting mitochondrial membrane potential via polymeric nanoparticles in a PC-3 cell line

It is demonstrated that co-delivery with HSP via polymeric NPs might have better therapeutic potential for in vitro management of androgen independent prostate cancer.



State of the art of nanocrystals--special features, production, nanotoxicology aspects and intracellular delivery.

  • R. MüllerS. GohlaC. Keck
  • Biology
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2011

Drug nanocrystals: In vivo performances.

Predictive modeling of insulin release profile from cross-linked chitosan microspheres.

Thermal analysis study of flavonoid solid dispersions having enhanced solubility

AbstractPurposes of this paper were to prepare and study new drug delivery systems for both flavanone glycosides and their aglycones based on solid-dispersion systems. These compounds are poor water

Molecular properties of WHO essential drugs and provisional biopharmaceutical classification.

The results suggest that a satisfactory bioequivalence (BE) test for more than 55% of the high-solubility Class 1 and Class 3 drug products on the WHO Essential Drug List may be based on an in vitro dissolution test.

Dissolution enhancement of flavonoids by solid dispersion in PVP and PEG matrixes: A comparative study

Polyvinylpyrrolidone (PVP) and poly(ethylene glycol) (PEG) solid dispersion systems with flavanone glycosides, naringin and hesperidin, and their aglycones, naringenin and hesperetin, were prepared,

Mechanistic Investigation of Pluronic® Based Nano-crystalline Drug-polymer Solid Dispersions

The size of drug crystallites in the drug-polymer solid dispersions is independent of polymer topology, but is caused kinetically by a combined effect of nucleation rate and crystal growth rate.