Oral bioavailability and pharmacodynamic activity of hesperetin nanocrystals generated using a novel bottom-up technology.

@article{Shete2015OralBA,
  title={Oral bioavailability and pharmacodynamic activity of hesperetin nanocrystals generated using a novel bottom-up technology.},
  author={Ganesh Shete and Yogesh B. Pawar and Kaushik Thanki and Sanyog Jain and Arvind Kumar Bansal},
  journal={Molecular pharmaceutics},
  year={2015},
  volume={12 4},
  pages={
          1158-70
        }
}
In the present study, nanocrystalline solid dispersion (NSD) was developed to enhance the release rate and oral bioavailability of hesperetin (HRN). NSD of HRN was prepared using a novel bottom-up technology platform. It is a spray drying based technology to generate solid particles, containing drug nanocrystals dispersed in small molecule excipients. HRN and mannitol were used in a 5:5 ratio, and an average crystallite size of HRN in NSD with mannitol was found to be 137.3 ± 90.0 nm. An in… 

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