Oral benfotiamine reverts cognitive deficit and increase thiamine diphosphate levels in the brain of a rat model of neurodegeneration

  title={Oral benfotiamine reverts cognitive deficit and increase thiamine diphosphate levels in the brain of a rat model of neurodegeneration},
  author={Ruan Carlos Mac{\^e}do de Moraes and Monique P. Singulani and {\'A}lisson de Carvalho Gonçalves and Guilherme Vannucchi Portari and Andr{\'e}a S. Torr{\~a}o},
  journal={Experimental Gerontology},
It is well known that patients with Alzheimer's disease (AD) have imbalances in blood thiamine concentrations and lower activity of thiamine-dependent enzymes. Benfotiamine, a more bioavailable thiamine analog, has been proposed as an alternative to counteract these changes related to thiamine metabolism. Thus, our study aimed to analyze the effects of benfotiamine supplementation on brain thiamine absorption, as well as on parameters related to neuronal energy metabolism and disease… Expand
5 Citations
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