Oral azole drugs as systemic antifungal therapy.

  title={Oral azole drugs as systemic antifungal therapy.},
  author={Jackson A Como and William E Dismukes},
  journal={The New England journal of medicine},
  volume={330 4},
The oral azole drugs--ketoconazole, fluconazole, and itraconazole--represent a major advance in systemic antifungal therapy. Among the three, fluconazole has the most attractive pharmacologic profile, including the capacity to produce high concentrations of active drug in cerebrospinal fluid and urine. Ketoconazole, the first oral azole to be introduced, is less well tolerated than either fluconazole or itraconazole and is associated with more clinically important toxic effects, including… CONTINUE READING


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