Oral application of Escherichia coli bacteriophage: safety tests in healthy and diarrheal children from Bangladesh

@article{Sarker2017OralAO,
  title={Oral application of Escherichia coli bacteriophage: safety tests in healthy and diarrheal children from Bangladesh},
  author={Shafiqul Alam Sarker and Bernard Berger and Ying Deng and Silas Kieser and Francis Foata and Deborah Moine and Patrick Descombes and Shamima Sultana and Sayeeda Huq and Pradip Kumar Bardhan and Val{\'e}rie Vuillet and Fabienne Praplan and Harald Br{\"u}ssow},
  journal={Environmental Microbiology},
  year={2017},
  volume={19},
  pages={237–250}
}
A T4-like coliphage cocktail was given with different oral doses to healthy Bangladeshi children in a placebo-controlled randomized phase I safety trial. Fecal phage detection was oral dose dependent suggesting passive gut transit of coliphages through the gut. No adverse effects of phage application were seen clinically and by clinical chemistry. Similar results were obtained for a commercial phage preparation (Coliproteus from Microgen/Russia). By 16S rRNA gene sequencing, only a low degree… 

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