Oral antioxidant therapy improves endothelial function in Type 1 but not Type 2 diabetes mellitus.

@article{Beckman2003OralAT,
  title={Oral antioxidant therapy improves endothelial function in Type 1 but not Type 2 diabetes mellitus.},
  author={Joshua A Beckman and Allison B. Goldfine and Mary Gordon and L. Anne Garrett and John F. Keaney and Mark A. Creager},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={285 6},
  pages={H2392-8}
}
Oxidative stress decreases the bioavailability of endothelium-derived nitric oxide in diabetic patients. We investigated whether impaired endothelium-dependent vasodilation (EDV) in diabetes can be improved by long-term administration of oral antioxidants. Forty-nine diabetic subjects [26 Type 1 (T1) and 23 Type 2 (T2)] and 45 matched healthy control subjects were randomized to receive oral vitamin C (1,000 mg) and vitamin E (800 IU) daily or matching placebo for 6 mo. Vascular ultrasonography… CONTINUE READING

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Impaired endothelium-dependent vasodila H2397 ANTIOXIDANTS AND DIABETES AJP-Heart

  • MT Johnstone, SJ Creager, KM Scales, JA Cusco, BK Lee, MA. Creager
  • Circ Physiol
  • 2003
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