Oral antidiabetic agents. The emergence of alpha-glucosidase inhibitors.

  title={Oral antidiabetic agents. The emergence of alpha-glucosidase inhibitors.},
  author={Harold E. Lebovitz},
  volume={44 Suppl 3},
Hyperglycaemia in patients with non-insulin-dependent diabetes mellitus (NIDDM) results from impaired insulin action and/or deficient insulin secretion. These abnormalities lead to increased hepatic glucose production, the primary cause of fasting hyperglycaemia, and decreased peripheral glucose uptake, the major mechanism responsible for postprandial hyperglycaemia. Hyperglycaemia in patients with NIDDM can be decreased by several different mechanisms: (1) a decrease in nutrient ingestion; (2… CONTINUE READING


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