Oral anticoagulants: pharmacodynamics, clinical indications and adverse effects.

@article{Freedman1992OralAP,
  title={Oral anticoagulants: pharmacodynamics, clinical indications and adverse effects.},
  author={Michael D. Freedman},
  journal={Journal of clinical pharmacology},
  year={1992},
  volume={32 3},
  pages={196-209}
}
Discovered early in this century consequent to investigations of a bovine hemorrhagic disease, the oral anticoagulants inhibit a post translational modification required for various hepatically derived serine proteases to become active. These include Factors II, V, VII and X. Through their effect on Proteins S and C, the extrinsic pathway is also effected. While most of these agents exist as optically active enantiomers, with differing kinetics and pharmacologic profiles, they are generally… CONTINUE READING