Oral anticoagulants: Pharmacogenetics Relationship between genetic and non-genetic factors.

  title={Oral anticoagulants: Pharmacogenetics Relationship between genetic and non-genetic factors.},
  author={G D'andrea and Rosa Lucia D'Ambrosio and Maurizio Margaglione},
  journal={Blood reviews},
  volume={22 3},
Oral anticoagulants, the main drugs used for the prevention and treatment of thromboembolic diseases, exhibit a greater than 10-fold inter-individual variability in the dose requirement to achieve a therapeutic response. The relationship between the dose prescribed and the individual response is regulated by genetic and environmental factors. In particularly, molecular analysis of two genes, encoding for the enzyme responsible for the warfarin (S)-isoform catabolism (CYP2C9) and for the target… CONTINUE READING

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