Oral and dental manifestations of vitamin D-dependent rickets type I: report of a pediatric case.

@article{Zambrano2003OralAD,
  title={Oral and dental manifestations of vitamin D-dependent rickets type I: report of a pediatric case.},
  author={Marlene Germania Leg{\~n}a Zambrano and Nikolaos G. Nikitakis and Mar{\'i}a del Carmen S{\'a}nchez-Quevedo and John J. Sauk and Heddie O. Sedano and Helen Rivera},
  journal={Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics},
  year={2003},
  volume={95 6},
  pages={
          705-9
        }
}
Vitamin D-dependent rickets type I (VDDRI) represents an autosomal recessive hereditary defect in vitamin D metabolism. Patients with VDDRI have mutations of chromosome 12 that affect the gene for the enzyme 1-alpha-hydroxylase, resulting in decreased levels of 1,25(OH)(2) vitamin D. Clinical features include growth failure, hypotonia, weakness, rachitic rosary, convulsions, tetany, open fontanels, and pathologic fractures. The oral and dental manifestations of VDDRI have not been described… Expand
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TLDR
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TLDR
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TLDR
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TLDR
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A 15-year-old boy with XLH visited the authors' facility complaining of a toothache in the left lower canine region, and had multiple periodontal abscesses, but no evidence of dental caries, trauma, orperiodontal disease on the corresponding teeth at the time of his oral examination. Expand
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It was felt that in all probability dentinogenesis was disturbed by the DDR type II, and oral hygiene for caries prevention is the most important procedure, because the pulp will be infected immediately after initiation of dental caries. Expand
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Two distinct hereditary defects, vitamin D‐dependent rickets type I and type II, have been recognized in vitamin D metabolism and are characterized by the early onset of severe rickets and associated alopecia. Expand
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Vitamin D-dependent rickets type I (VDDR-I), also known as pseudo-vitamin D-deficiency rickets, appears to result from deficiency of renal vitamin D 1alpha-hydroxylase activity. Prior work has shownExpand
Genetics of Vitamin D 1α-Hydroxylase Deficiency in 17 Families
Vitamin D-dependent rickets type I (VDDR-I), also known as pseudo-vitamin D-deficiency rickets, appears to result from deficiency of renal vitamin D 1alpha-hydroxylase activity. Prior work has shownExpand
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