Oral and Systemic Effects of Xylitol Consumption

  title={Oral and Systemic Effects of Xylitol Consumption},
  author={S J Janket and Jaspreet Benwait and Pauline Isaac and Leland K. Ackerson and Jukka H. Meurman},
  journal={Caries Research},
  pages={491 - 501}
Recent results of randomized trials testing the efficacy of xylitol in caries prevention have been conflicting. This narrative review reveals the sources of discrepancy. The following databases were searched for the terms “xylitol” or “artificial sweeteners” restricted to the English language: PubMed, Web of Science, Evidenced-Based Medicine, Scopus, and the Cochrane database. In a separate search, the terms “dental caries” or “cariogenicity” or “glucosyltransferase” or “low glycemic” or “low… Expand
9 Citations
Health benefits of xylitol
Xylitol can reduce constipation, diabetes, obesity, and other body syndromes or illnesses; it has also revealed its stimulating effect on digestion and immune system; it can produce some side effects such as irritable bowel syndrome, diarrhea, nephrolithiasis, etc., when consumed in excessive amounts. Expand
A systematic review and meta-analysis of the role of sugar-free chewing gum on Streptococcus mutans
There is a need for future research exploring the use of SFG as a preventive measure for reducing the cariogenic oral bacterial load, and the degree of variability in the effect and the moderate quality of the trials included are considered. Expand
Differences in Sweet Taste Perception and Its Association with the Streptococcus mutans Cariogenic Profile in Preschool Children with Caries
The results of this study suggest the future use of taste preferences in children as a diagnostic tool for the early detection of increased susceptibility to caries through microbial dysbiosis towards specific species of microorganisms. Expand
Antimicrobial Activity, Biocompatibility and Anti-inflammatory Properties of Cetylpyridinium Chloride-based Mouthwash Containing Sodium Fluoride and Xylitol: An In Vitro Study.
Using an oral epithelial cell model, the CPC-based mouthwashes were found to be less cytotoxic than a chlorhexidine-containing mouthwash used as control and to be biocompatible and to exhibit anti-inflammatory activity. Expand
Secondary oxalosis induced by xylitol concurrent with lithium-induced nephrogenic diabetes insipidus: a case report
Patients receiving lithium therapy must be closely monitored during the perioperative period, and rehydration therapy using xylitol infusion should be avoided in such cases. Expand
Nonrestorative Management of Dental Caries
Strategy adoption for the nonrestorative management of dental caries prolongs the life span of the teeth and sustains the good oral health of patients and is divided into four components to address the different etiological factors of dental Caries. Expand
Low-Glycemic-Index/Load Desserts Decrease Glycemic and Insulinemic Response in Patients with Type 2 Diabetes Mellitus
Consumption of low-GI/GL dessert indicates a positive impact on metabolic parameters in T2DM patients, and hunger, additional food, and additional food quantity VAS ratings were significantly lower after the consumption of the low- GI/GLessert compared to control. Expand
Characterisation of a catalytic triad and reaction selectivity in the dual mechanism of the catalyse hydride transfer in xylitol phosphate dehydrogenase.
The main goal of this work is to analyse the conformational changes of XPDH-bound ligands such as zinc, NADH, XU5P, and RU5P to elucidate the key amino acids involved in the substrate binding to increase the catalysis efficiency of xylitol production in the industry. Expand


Are We Ready for Definitive Clinical Guidelines on Xylitol/Polyol Use?
Most experts agree that well-designed, placebo-controlled randomized clinical trials (RCTs) are still needed in target populations worldwide to reach definitive caries-preventive/therapeutic recommendations. Expand
Results from the Xylitol for Adult Caries Trial (X-ACT).
Daily use of xylitol lozenges did not result in a statistically or clinically significant reduction in 33-month caries increment among adults at an elevated risk of developing caries, suggesting thatxylitol used as a supplement in adults does not reduce their caries experience significantly. Expand
Effect of xylitol and sorbitol on plaque acidogenesis.
The regular consumption of xylitol lozenge modifies dental plaque, resulting in a marked reduction in the plaque acidogenicity, which could not be detected using sorbitol lozenges, and could have an additional benefit in caries prevention. Expand
Effects of Xylitol Wipes on Cariogenic Bacteria and Caries in Young Children
Dailyxylitol-wipe application significantly reduced the caries incidence in young children as compared with wipes without xylitol, suggesting that the use of xylitor wipes may be a useful adjunct for caries control in infants. Expand
Are sugar-free confections really beneficial for dental health?
It is concluded that polyol-based sugar-free products may decrease dental caries incidence but they may bring another dental health risk, dental erosion, if they contain acidic flavouring. Expand
The caries-preventive effect of xylitol/maltitol and erythritol/maltitol lozenges: results of a double-blinded, cluster-randomized clinical trial in an area of natural fluoridation.
The results suggest that in relatively low-caries conditions the school-based use of xylitol/maltitol or erythritol/ maltitol lozenges would not have additional caries-preventive effect when compared with comprehensive prevention. Expand
Effects of maltitol and xylitol chewing-gums on parameters involved in dental caries development.
Sugar free CG sweetened with either maltitol or xylitol can similarly reduce plaque acidogenicity compared to gum base through a decrease in oral bacteria presence. Expand
Turku sugar studies XVIII. Incidence of dental caries in relation to 1-year consumption of xylitol chewing gum.
The results show a profound difference in the caries increment rate between the two experimental groups, which clearly indicate a therapeutic, caries inhibitory effect of xylitol. Expand
The Effects of Sucralose, Xylitol, and Sorbitol on Remineralization of Caries Lesions in Rats
The results show that removal of the cariogenic challenge allowed remineralization to occur and that no sweetening agent was superior to another in this respect. Expand
The Effectiveness of Xylitol in a School-Based Cluster-Randomized Clinical Trial
Xylitol consumption did not have additional benefit beyond other preventive measures, and caries progression in the permanent teeth of both groups was minimal, suggesting that other simultaneous prevention modalities may have masked the possible beneficial effects of xylitol in this trial. Expand