Oral and Intestinal Microbial Features in Pregnant Women with Hypothyroidism and Their Correlations with Pregnancy Outcomes.

  title={Oral and Intestinal Microbial Features in Pregnant Women with Hypothyroidism and Their Correlations with Pregnancy Outcomes.},
  author={Biao Wang and Yajuan Xu and Miao Zhang and Jingzhe Zhang and Xiaofeng Hou and Jingjing Li and Yanjun Cai and Zongzong Sun and Yanjie Ban and Wentao Wang},
  journal={American journal of physiology. Endocrinology and metabolism},
  • Biao WangYajuan Xu Wentao Wang
  • Published 5 October 2020
  • Medicine, Biology
  • American journal of physiology. Endocrinology and metabolism
OBJECTIVE To explore the characteristics of oral and intestinal microbiota of pregnant women with hypothyroidism during pregnancy, and to find the correlations between the changes of flora and pregnancy outcome of pregnant women with hypothyroidism during pregnancy. METHODS In this study, oral and intestinal microbial composition was surveyed using 16S rRNA sequencing approach in 61 pregnant women (30 with hypothyroidism and 31 normal controls). Sequentially, we validated the differential… 

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It is suggested that pregnancy, especially in the early periods, promotes the proliferation of microorganisms in the oral cavity and facilitates a colonization of periodontal pathogens.

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