Oral and Intestinal Microbial Features in Pregnant Women with Hypothyroidism and Their Correlations with Pregnancy Outcomes.

@article{Wang2020OralAI,
  title={Oral and Intestinal Microbial Features in Pregnant Women with Hypothyroidism and Their Correlations with Pregnancy Outcomes.},
  author={Biao Wang and Yajuan Xu and Miao Zhang and Jingzhe Zhang and Xiaofeng Hou and Jingjing Li and Yanjun Cai and Zongzong Sun and Yanjie Ban and Wentao Wang},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2020}
}
  • Biao WangYajuan Xu Wentao Wang
  • Published 5 October 2020
  • Medicine, Biology
  • American journal of physiology. Endocrinology and metabolism
OBJECTIVE To explore the characteristics of oral and intestinal microbiota of pregnant women with hypothyroidism during pregnancy, and to find the correlations between the changes of flora and pregnancy outcome of pregnant women with hypothyroidism during pregnancy. METHODS In this study, oral and intestinal microbial composition was surveyed using 16S rRNA sequencing approach in 61 pregnant women (30 with hypothyroidism and 31 normal controls). Sequentially, we validated the differential… 

Plasma Lipid Profile and Intestinal Microflora in Pregnancy Women With Hypothyroidism and Their Correlation With Pregnancy Outcomes

The lipid profile and intestinal microflora of pregnant women with hypothyroidism significantly differed from those of normal pregnant women and were associated with adverse pregnancy outcomes.

MICROBIOTA AND PREGNANCY

The major findings within the past year support the notions of gut, oral and vaginal microbial stability during pregnancy, including species level stool microbiota differences in women with and without Gestational diabetes, which may in future have value for monitoring of gestational diabetes.

Oral microflora and pregnancy: a systematic review and meta-analysis

The results from meta-analyses were inconclusive since limited studies reported outcomes on the same measuring scale, and more future studies are needed to elucidate the association between pregnancy oral microbiota and maternal oral/systemic health and birth outcomes.

Differential lipids in pregnant women with subclinical hypothyroidism and their correlation to the pregnancy outcomes

The lipid profile of pregnant women with SCH is significantly different from that of healthy pregnant women, and lipid molecules associated with the differential lipid metabolism, such as SM, phosphatidylethanolamine (PE), and PI should be further investigated for their roles in the pathogenesis of SCH in pregnancy.

Effect of Levothyroxine Sodium Tablets on Pregnancy Outcome and Offspring Development Quotient of SCH during Pregnancy

Levothyroxine sodium tablets (L-T4) can not only improve the pregnancy outcome of patients with SCH during pregnancy but also play a positive role in improving the neurointellectual development of their offspring.

Randomized Clinical Trial: Probiotics Alleviated Oral-Gut Microbiota Dysbiosis and Thyroid Hormone Withdrawal-Related Complications in Thyroid Cancer Patients Before Radioiodine Therapy Following Thyroidectomy

Background Thyroid hormone withdrawal (THW) in postoperative thyroid cancer patients who need always accompanied by complications (e.g., dyslipidemia and constipation). At present, there are no

Gut microbiome and thyroid autoimmunity.

Dietary Succinoglycan Riclin Improves Glycemia Control in Mice with Type 2 Diabetes.

Dietary riclin enriched the diversity of gut microflora and restored the relative abundance of several bacterial genera in diabetes, including the strains of Clostridium, Parasutterella, Klebsiella, and Bacteroides, suggesting that riclin has potential to be a functional food to treat T2D.

Clinical Biochemical Indicators and Intestinal Microbiota Testing Reveal the Influence of Reproductive Age Extending from the Mother to the Offspring

New evidence is provided to explain the increased adverse pregnancy outcomes of mothers of inappropriate age, describe the increased health risks of newborns, and contribute to the discovery of mother-child bonds for a better understanding of healthy reproduction.

References

SHOWING 1-10 OF 38 REFERENCES

Significant increase of oral bacteria in the early pregnancy period in Japanese women

It is suggested that pregnancy, especially in the early periods, promotes the proliferation of microorganisms in the oral cavity and facilitates a colonization of periodontal pathogens.

Stability of the vaginal, oral, and gut microbiota across pregnancy among African American women: the effect of socioeconomic status and antibiotic exposure

Measures of maternal socioeconomic status are variably associated with changes in diversity across pregnancy for the vaginal, oral, and gut microbiota, with minimal attenuation by prenatal antibiotic exposure.

Molecular estimation of alteration in intestinal microbial composition in Hashimoto's thyroiditis patients.

Gut dysbiosis is associated with primary hypothyroidism with interaction on gut-thyroid axis.

This study suggests that primary hypothyroidism causes changes in gut microbiome, which can affect thyroid function in mice and might be further used to develop potential probiotics to facilitate the adjuvant treatment of this disease.

Gut Microbiota Composition in Mid-Pregnancy Is Associated with Gestational Weight Gain but Not Prepregnancy Body Mass Index

The aim was to analyze associations between maternal overweight/obesity, as well as gestational weight gain (GWG) and GMC, and the modifying effect of depression and anxiety symptom scores on weight andGMC.

Association between hypothyroidism and small intestinal bacterial overgrowth.

The history of overt hypothyroidism is associated with bacterial overgrowth development and excess bacteria could influence clinical gastrointestinal manifestations, however, fermenting carbohydrate luminal bacteria do not interfere with thyroid hormone levels.

Intake of probiotic food and risk of preeclampsia in primiparous women: the Norwegian Mother and Child Cohort Study.

It is suggested that regular consumption of milk-based probiotics could be associated with lower risk of preeclampsia in primiparous women.

Hypothyroidism in pregnancy.

Intestinal microbiota, diet and health

The present review provides a comprehensive, updated overview of the human gut microbiota, the factors influencing its composition and the role of probiotics as a therapeutic modality in the treatment and prevention of diseases and/or restoration of human health.