Oral administration of the growth hormone secretagogue NN703 in adult patients with growth hormone deficiency

@article{Svensson2003OralAO,
  title={Oral administration of the growth hormone secretagogue NN703 in adult patients with growth hormone deficiency},
  author={Johan Svensson and John P. Monson and Thorsten Vetter and Troels Krarup Hansen and Rachel Savine and Peter Herbert Kann and Mieke Bex and Martin Reincke and Claus Hagen and Albert Beckers and Mbelenge Mapoko Ilondo and M Jasmina Zdravkovic and Bengt-{\aa}ke Bengtsson and M{\'a}rta Korbonits},
  journal={Clinical Endocrinology},
  year={2003},
  volume={58}
}
objective Little is known of the usefulness of GH secretagogues (GHSs) in GH‐deficient (GHD) adults. The objective of this study was to determine the number of responders to treatment with NN703 in GHD adults. 
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Growth hormone secretagogues: history, mechanism of action, and clinical development
TLDR
This review will focus on the research history and the pharmacology of each GHS, which reached randomized clinical trials, and highlight the publicly disclosed clinical trials regarding GHSs.
Role of ghrelin in growth hormone-deficient patients
TLDR
Even though ghrelin does not seem to be abnormal in patients with classic GHD, these patients constitute an interesting model for studying GH- and adrenocorticotropic hormone-independent effects of gh Relin.
[Ghrelin and growth hormone secretagogues (GHS): modulation of growth hormone secretion and therapeutic applications].
TLDR
The available data on the discovery of this peptide, the mechanisms of action and possible physiological roles of the GHS and ghrelin on GH secretion, and finally, the possible therapeutic applications of these compounds are reviewed.
Pharmacodynamic hormonal effects of anamorelin, a novel oral ghrelin mimetic and growth hormone secretagogue in healthy volunteers.
  • Jose M Garcia, W. Polvino
  • Medicine, Biology
    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
  • 2009
[News options and preparations in growth hormone therapy].
TLDR
The oral secretagogues have not proved efficacy to be used in clinical practice and the slow- release preparations of GH and GH releasing hormone that could improve the patient's compliance will need to be studied considering long term efficacy and safety.
Ghrelin and growth hormone secretagogues, physiological and pharmacological aspect.
TLDR
It is likely that GHSs, acting as either agonists or antagonists on different pathophysiological processes, might have some other clinical impact and therapeutic potential, at least theoretically ghrelin receptor antagonists could be anti-obesity drugs, as blockers of the orexigenic signal from the gastrointestinal tract to the brain.
Review Article Integrating Ghs into the Ghrelin System 1. Overview
Integrating GHS into the Ghrelin System
Oligopeptide derivatives of metenkephalin were found to stimulate growth-hormone (GH) release directly by pituitary somatotrope cells in vitro in 1977. Members of this class of peptides and…
Adult growth hormone replacement: current understanding.
  • R. Murray
  • Medicine, Biology
    Current opinion in pharmacology
  • 2003
Recombinant human growth hormone therapy in HIV-associated wasting and visceral adiposity
  • M. Yin, M. Glesby
  • Medicine, Biology
    Expert review of anti-infective therapy
  • 2005
TLDR
Recombinant human growth hormone therapy has a clear dose-dependent impact on trunk and visceral fat in HIV-infected patients with central fat accumulation, resulting in improvements in perception of body image and a beneficial effect on lipid parameters.
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