Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task

@article{PrezGarca2005OralAO,
  title={Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task},
  author={Georgina P{\'e}rez-Garc{\'i}a and Alfredo Meneses},
  journal={Pharmacology Biochemistry and Behavior},
  year={2005},
  volume={81},
  pages={673-682}
}

Effects of 5-HT6 antagonists, Ro-4368554 and SB-258585, in tests used for the detection of cognitive enhancement and antipsychotic-like activity

The overall efficacy of Ro-4368554 and SB-258585 in animal models for AD and schizophrenia is rather limited, and data show moderate efficacy in some models forAD but do not support the therapeutic potential of 5-HT6 antagonists for schizophrenia.

E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat

This is the first study to demonstrate that E-6801, a potent 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission.

E-6801, a 5-HT 6 receptor agonist, improves recognition memory by combined modulation of cholinergic

This is the first study to demonstrate that E-6801, a potent 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission.
...

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  • A. Meneses
  • Biology, Psychology
    Drug news & perspectives
  • 2001
Injection of the 5-HT(6) receptor antagonist Ro-04-6790 improved learning consolidation in an autoshaping task, while mCPP, scopolamine and dizocilpine decreased performance, and a series of Ro- 04-67 90 analogues that penetrate the brain and specifically bind to 5- HT(6%) receptors reversedScopolamine-induced retention deficit in a passive avoidance learning test.