Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats.

@article{Shinozaki2000OralAO,
  title={Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats.},
  author={Kazuya Shinozaki and Yoshihiko Nishio and Takehiko Okamura and Yuko Yoshida and Hiroshi Maegawa and Hirohiko Kojima and Masahiro Masada and Noboru Toda and Ryuichi Kikkawa and Atsunori Kashiwagi},
  journal={Circulation research},
  year={2000},
  volume={87 7},
  pages={566-73}
}
We have reported that a deficiency of tetrahydrobiopterin (BH(4)), an active cofactor of endothelial NO synthase (eNOS), contributes to the endothelial dysfunction through reduced eNOS activity and increased superoxide anion (O(2)(-)) generation in the insulin-resistant state. To further confirm this hypothesis, we investigated the effects of dietary treatment with BH(4) on endothelium-dependent arterial relaxation and vascular oxidative stress in the aortas of insulin-resistant rats. Oral… CONTINUE READING