Oral administration of rutoside can ameliorate inflammatory bowel disease in rats.

@article{Cruz1998OralAO,
  title={Oral administration of rutoside can ameliorate inflammatory bowel disease in rats.},
  author={Tony Cruz and Julio G{\'a}lvez and Maria Angeles Ocete and Maria Elena Crespo and F S{\'a}nchez de Medina L-H and Antonio Zarzuelo},
  journal={Life sciences},
  year={1998},
  volume={62 7},
  pages={687-95}
}
Rutoside, a flavonoid with antioxidant properties, was tested for acute and chronic antiinflammatory activity in trinitrobenzenesulfonic acid-induced rat colitis. Pretreatment with 10 or 25 mg/kg of rutoside by the oral route reduced colonic damage at 2 days. Several mechanisms can be involved in this activity, and one of these may be related to its ability in preventing glutathione depletion of colitic animals, and this could result in mucosal protection against oxidative insult. When rutoside… CONTINUE READING
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