Oral administration of putrescine inhibits Cryptosporidium parvum infection of neonatal C57BL-6 mice and is independent of nitric oxide synthesis.

@article{Waters1997OralAO,
  title={Oral administration of putrescine inhibits Cryptosporidium parvum infection of neonatal C57BL-6 mice and is independent of nitric oxide synthesis.},
  author={W Ray Waters and Timothy A. Reinhardt and James A. Harp},
  journal={The Journal of parasitology},
  year={1997},
  volume={83 4},
  pages={746-50}
}
We examined the efficacy of oral administration of putrescine (a byproduct of arginine metabolism) in the prevention of Cryptosporidium parvum infection of neonatal C57BL-6 mice. Mice were challenged with the parasite at 7 days of age. Mice receiving putrescine from 3 through 10 days of age had a delayed pattern of infection as compared with control mice. Mice receiving putrescine from 3 through 21 days of age did not become infected, whereas control mice were heavily infected. We also tested… CONTINUE READING