Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse

@article{Murakami1994OralAO,
  title={Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse},
  author={Masao Murakami and Takeshi Tsubata and Reiko Shinkura and Sazuku Nisitani and Mitsunori Okamoto and Hideo Yoshioka and Takashi Usui and Shigeki Miyawaki and T. Honjo},
  journal={The Journal of Experimental Medicine},
  year={1994},
  volume={180},
  pages={111 - 121}
}
About a half of the antierythrocyte autoantibody transgenic (autoAb Tg) mice, in which almost all B cells are detected in the spleen, lymph nodes, and Peyer's patches, but not in the peritoneal cavity, suffer from autoimmune hemolytic anemia. The occurrence of this disease is strongly linked to production of autoAb by activated peritoneal B-1 cells in the Tg mice. In this study, we have shown that oral administration of lipopolysaccharides (LPS) activated B-1 cells in the lamina propria of the… CONTINUE READING

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