Oral administration of insulin as poly(vinyl alcohol)-gel spheres in diabetic rats.

@article{Kimura1996OralAO,
  title={Oral administration of insulin as poly(vinyl alcohol)-gel spheres in diabetic rats.},
  author={T. D. Kimura and Kazuo Sato and Kiho Sugimoto and Rui Tao and Tadahiro Murakami and Yuji Kurosaki and Taiji Nakayama},
  journal={Biological & pharmaceutical bulletin},
  year={1996},
  volume={19 6},
  pages={897-900}
}
The oral administration of insulin in poly(vinyl alcohol)-gel spheres (PVA-GS), an oral dosage form with prolonged residence time in the ileum, was examined in streptozotocin-induced diabetic rats. Intragastric administration of PVA-GS containing insulin and a protease inhibitor, aprotinin or bacitracin, caused a significant and prolonged reduction of blood glucose levels, suggesting insulin absorption. The bioavailability of insulin estimated from the hypoglycemic effect was about 2% in the… CONTINUE READING

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