Oral administration of human papillomavirus type 16 E7 displayed on Lactobacillus casei induces E7-specific antitumor effects in C57/BL6 mice.

@article{Poo2006OralAO,
  title={Oral administration of human papillomavirus type 16 E7 displayed on Lactobacillus casei induces E7-specific antitumor effects in C57/BL6 mice.},
  author={Haryoung Poo and Hyun-Mi Pyo and Tae-Young Lee and Sun-Woo Yoon and Jong-Soo Lee and Chul-Joong Kim and M. -H. Sung and Seunghoon Lee},
  journal={International journal of cancer},
  year={2006},
  volume={119 7},
  pages={1702-9}
}
The mounting of a specific immune response against the human papillomavirus type 16 E7 protein (HPV16 E7) is important for eradication of HPV16 E7-expressing cancer cells from the cervical mucosa. To induce a mucosal immune response by oral delivery of the E7 antigen, we expressed the HPV16 E7 antigen on the surface of Lactobacillus casei by employing a novel display system in which the poly-gamma-glutamic acid (gamma-PGA) synthetase complex A (PgsA) from Bacillus subtilis (chungkookjang) was… CONTINUE READING
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